Company news_Reindeer Biotech Co. Ltd

Another major breakthrough in traditional Chinese medicine after artemisinin - epimedium extract in the treatment of advanced liver cancer

Epimedium is a plant that can be used as a whole herb for medicinal purposes. In traditional Chinese medicine, it is mainly used to treat impotence and premature ejaculation, backache and leg pain, numbness of limbs, hemiplegia, neurasthenia, forgetfulness, tinnitus, and dizziness. On May 19, 2021, at the annual meeting of the American Society of Clinical Oncology (ASCO), my country's self-developed small-molecule immunogen drug, icariin (alcoradine) first-line treatment of advanced hepatocellular carcinoma Phase III research results were released for the first time . In June, the international cancer academic journal "Cancer Science" (Cancer Science) published online, the phase II clinical trial of the natural small molecule drug Acradine (First-in-class, icariin) immunomodulatory treatment of advanced hepatocellular carcinoma result. The study was led by Academician Sun Yan and Professor Qin Shukui, famous oncologists in my country, and was completed in cooperation with clinical research centers of many hospitals across the country. Acradine is a small-molecule drug produced by enzymatic hydrolysis of Epimedium extract isolated from the traditional Chinese medicine Epimedium. It has multi-target anti-inflammatory and anti-tumor immunomodulatory biological activities. / Phase II trials have obtained preliminary verification of safety and efficacy. Acradine (SNG-162, common name is icariin) is an active drug monomer extracted, separated and purified from Epimedium. It is considered to be another major breakthrough in the modernization of traditional Chinese medicine after artemisinin. Since September 2017, a total of 283 patients with advanced hepatocellular carcinoma have been included in the study, of which 71 patients had a positive comprehensive biomarker score and were associated with advanced Barcelona stage (BCLC stage C), HBV infection and thrombocytopenia and other risks or 33 patients were treated with icariin; 38 patients were treated with cinobufacin. The median follow-up time was 8.1 months (cut-off date: December 30, 2020), and the valid research data was as of November 2, 2020. It showed that in the enriched population of compound biomarkers, it was found The median survival (mOS) was significantly better than that of the control group treated with cinobufacin, which were 13.5 months and 6.8 months, respectively, indicating that alkoladine can indeed significantly reduce the risk of death in patients with advanced liver cancer, reaching 57%, which has a significant Survival advantage, which is very valuable. On the other hand, the advantages of Acradine are also reflected in the relatively good safety data. The incidence of drug-related adverse reactions of grade 3 and above is only 15%, which is consistent with the safety data of the past phase I and II clinical trials. Lading has good security. Analysis conclusion: The small-molecule immunomodulator icariin can significantly improve the overall survival rate of patients with unfavorable comprehensive biomarker score-positive enriched hepatitis B virus (HBV)-associated advanced liver cancer with a favorable safety profile. At present, the drug has submitted an application for early marketing to the State Food and Drug Administration, which has been accepted and included in priority approval.

The effect of Cordyceps militaris extract on the skin

Cordyceps militaris is a rare medicinal fungus. Because it contains cordycepin, the symbolic component of the genus Cordyceps, it plays an important role in regulating the lungs and kidneys, regulating immunity, etc. In addition, the extract of Cordyceps militaris is also effective for the skin. Exercise fatigue and anti-oxidation also have a certain impact. In the paper "Prospects for the Application of Cordyceps and Its Components in Dermatology", it is mentioned that the antioxidant activity of Cordyceps is related to the content of certain components contained in Cordyceps. glycoside, adenine, D-mannitol, Cordyceps polysaccharides and polyamino acids, Cordyceps militaris has obvious anti-aging effect on the skin. Quality content and can increase the content of light proline in the skin, so as to play the role of anti-oxidation and delay skin aging. The skin-related effect of Cordyceps militaris extract is reflected in its main component, cordycepin, also known as cordycepin. In terms of skin care, it plays an anti-oxidant and anti-aging role. Shenzhen Tsinghua University Research Institute-Huayan Co-constructed Skin Health Research Center published a paper "The Mechanism and Application of Cordycepin in the Field of Skin Care" which proposed the main active ingredient of Cordyceps militaris extract in the field of skin care in recent years. The application has been on the rise, and his team found that cordycepin can play a role in skin immune regulation, treatment of inflammatory skin, repair of skin infection and improvement of skin through microneedle or penetration enhancer. This proves that Cordyceps militaris (cordycepin) has gained a certain degree of attention in the world, and the correlation between Cordyceps militaris extract and skin is being continuously explored. Looking forward to more discovery and development of cordycepin in the field of skin care.

What are the functions of various extracts, and what are the advantages of Cordyceps militaris extract?

With the continuous advancement of human science and technology, more and more traditional foods, traditional Chinese medicines, etc. have extraction technology. Cordyceps militaris extract is a small part of it, and all kinds of extracts have their important value, including some of our common meat and vegetables. Let's take a look at the important functions of these extracts. Rose flower extract Roses symbolize love, and most varieties of roses are also related to love. The extracts mainly include extraction powder and liquid extract, rose essential oil, etc. We can see that many cosmetics and women's skin care products contain rose extract ingredients. On the one hand, it is because roses are emotionally linked to women. The liver and stomach have a conditioning effect, and can eliminate fatigue and improve physical fitness. Aloe Vera Extract Aloe vera is also a common plant, and it is also deeply recognized by the public. Repairing and hydrating are the key words of aloe vera. Aloe extract is colorless and transparent, and masks made of aloe ingredients are very popular among women. Aloe vera extract has whitening, moisturizing, anti-allergic, skin repairing and other effects, and is one of the effective ingredients of many skin care products. Wolfberry Extract In recent years, wolfberry has become an online celebrity tonic. Wild wolfberry grows in the Loess Plateau and foothills on both sides of the Yellow River from Qinghai to Shanxi, but now most wolfberries are cultivated artificially. It is said on the Internet that wolfberry is closely related to men, and it is said that soaking wolfberry in a thermos cup is a tonic that modern young people love. Lycium barbarum has immune regulation, lowering blood sugar, lowering blood fat and other effects. Traditional Chinese medicine believes that it can improve symptoms such as liver and kidney yin deficiency, sore waist and knees, and dizziness. Its extract is even used in traditional Chinese medicine preparations. Cordyceps Extract Cordyceps extract mainly refers to Cordyceps militaris extract, which is extracted from Cordyceps as its main component, cordycepin. Modern medicine has proved that cordycepin is the main active ingredient in Cordyceps, and a reasonable extraction of Cordyceps extract with high content of cordycepin is Part of the modernization of traditional Chinese medicine. As a tonic that has been passed down for thousands of years in China, Cordyceps has a long cultural history and efficacy. With the help of Cordyceps militaris, the composition of cordycepin is extracted, which makes the modernization of Cordyceps come true. In addition to the above-mentioned extracts of plants and fungi, there are a wide variety of extracts from various animals, plants, and fungi, each with different functions and different application scenarios, which makes the development of modern food, cosmetics, and tonics more rapid. Consumers There are also more choices.

Tree extract: the natural power of skin care

As a species that has lived in the world for thousands of years, every crude tree has its own unique philosophy of life. Trees naturally have a set of survival mechanisms: water storage, growth and environmental defense. Therefore, many skin care ingredients extracted from natural trees can enhance the skin's resistance and keep the skin in a better state.

Holiday notice

New Year’s Day and the Spring Festival of 2021 is coming. Our holiday arrangements are as follows:

Met the suppliers of imported raw materials on December 5, 2020

On December 2, 2020, Deng Fang, general manager of Reindeer Biotech Co., Ltd. led the sales team to meet with the manufacturers of imported raw material processing products, which expanded business op

Notice on protection of coronavirus during epidemic period

During the Spring Festival in 2020, We ushered in a war without gunsmoke ,due to the severe situation of coronavirus pneumonia in China, the time of returning to work is prolonged.

All staff wish you good health and happiness in the New Year

In 2019, with the hard work of the staff and the innovation of our team, Reindeer Biotech Co., Ltd. overcame many difficulties and united to achieve the good performance of harmonious and stable staff